IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F146/2019.4

SLC22 family of organic cation and anion transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Bruno Hagenbuch1
  1. University of Kansas, USA


Abstract

The SLC22 family of transporters is mostly composed of non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role in drug disposition. The family may be divided into three subfamilies based on the nature of the substrate transported: organic cations (OCTs), organic anions (OATs) and organic zwiterrion/cations (OCTN). Membrane topology is predicted to contain 12 TM domains with intracellular termini, and an extended extracellular loop at TM 1/2.

Contents

This is a citation summary for SLC22 family of organic cation and anion transporters in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

SLC22 family of organic cation and anion transporters
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=146
    Organic cation transporters (OCT)
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=196
        Transporters
                OCT1(Organic cation transporter 1)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1019
                OCT2(Organic cation transporter 2)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1020
                OCT3(Organic cation transporter 3)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1021
    Organic zwitterions/cation transporters (OCTN)
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=197
        Transporters
                OCTN1(Organic cation/carnitine transporter 1)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1022
                OCTN2(Organic cation/carnitine transporter 2)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1023
                CT2(Carnitine transporter 2)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1024
    Organic anion transporters (OATs)
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=198
        Transporters
                OAT1(Organic anion transporter 1)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1025
                OAT2(Organic anion transporter 2)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1026
                OAT3(Organic anion transporter 3)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1027
                Organic anion transporter 4
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1030
                OAT5(Organic anion transporter 5)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1029
                OAT4(Organic anion transporter 7)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1028
    Urate transporter
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=199
        Transporters
                URAT1(Urate anion exchanger 1)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1031
    Orphan or poorly characterized SLC22 family members
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=200
        Transporters
                ORCTL3(Organic cation transporter-like 3)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1032
                ORCTL4(Organic cation transporter-like 4)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1033
                FLIPT1(Fly-like putative transporter 1)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1034
                BOIT(Brain-type organic cation transporter)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1035
                ORCTL2(Organic cation transporter-like 2)
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1036
                OAT6
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1037
                SLC22A23
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1038
                SLC22A24
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1039
                UST6
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1040
                solute carrier family 22 member 31
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2557
    Atypical SLC22B subfamily
    http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=859
        Transporters
                synaptic vesicle glycoprotein 2A
                http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2634

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