IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F146/2019.4
SLC22 family of organic cation and anion transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Bruno Hagenbuch1
- University of Kansas, USA
Abstract
The SLC22 family of transporters is mostly composed of non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role in drug disposition. The family may be divided into three subfamilies based on the nature of the substrate transported: organic cations (OCTs), organic anions (OATs) and organic zwiterrion/cations (OCTN). Membrane topology is predicted to contain 12 TM domains with intracellular termini, and an extended extracellular loop at TM 1/2.
Contents
This is a citation summary for SLC22 family of organic cation and anion transporters in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts.
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
SLC22 family of organic cation and anion transporters
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=146
Organic cation transporters (OCT)
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=196
Transporters
OCT1(Organic cation transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1019
OCT2(Organic cation transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1020
OCT3(Organic cation transporter 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1021
Organic zwitterions/cation transporters (OCTN)
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=197
Transporters
OCTN1(Organic cation/carnitine transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1022
OCTN2(Organic cation/carnitine transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1023
CT2(Carnitine transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1024
Organic anion transporters (OATs)
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=198
Transporters
OAT1(Organic anion transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1025
OAT2(Organic anion transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1026
OAT3(Organic anion transporter 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1027
Organic anion transporter 4
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1030
OAT5(Organic anion transporter 5)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1029
OAT4(Organic anion transporter 7)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1028
Urate transporter
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=199
Transporters
URAT1(Urate anion exchanger 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1031
Orphan or poorly characterized SLC22 family members
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=200
Transporters
ORCTL3(Organic cation transporter-like 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1032
ORCTL4(Organic cation transporter-like 4)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1033
FLIPT1(Fly-like putative transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1034
BOIT(Brain-type organic cation transporter)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1035
ORCTL2(Organic cation transporter-like 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1036
OAT6
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1037
SLC22A23
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1038
SLC22A24
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1039
UST6
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1040
solute carrier family 22 member 31
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2557
Atypical SLC22B subfamily
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=859
Transporters
synaptic vesicle glycoprotein 2A
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2634
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