IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F104/2019.4
Lanosterol biosynthesis pathway (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Helen E. Benson1
- University of Edinburgh, UK
Abstract
Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.
Contents
This is a citation summary for Lanosterol biosynthesis pathway in the
Guide to Pharmacology
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Database links
Lanosterol biosynthesis pathway
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=104
Introduction to Lanosterol biosynthesis pathway
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=104
Enzymes
acetyl-CoA acetyltransferase 1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2435
acetyl-CoA acetyltransferase 2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2436
hydroxymethylglutaryl-CoA synthase 1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=638
hydroxymethylglutaryl-CoA synthase 2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2432
hydroxymethylglutaryl-CoA reductase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639
mevalonate kinase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=640
phosphomevalonate kinase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=641
diphosphomevalonate decarboxylase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=642
isopentenyl-diphosphate Δ-isomerase 1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=646
isopentenyl-diphosphate Δ-isomerase 2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=647
geranylgeranyl diphosphate synthase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=643
farnesyl diphosphate synthase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=644
squalene synthase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645
squalene monooxygenase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2433
lanosterol synthase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2434
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