IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F89/2019.4
1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Donald P. McDonnell1 and
Rachid Safi1
- Duke University, USA
Abstract
Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [68]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [71].
Contents
This is a citation summary for 1H. Liver X receptor-like receptors in the
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Database links
1H. Liver X receptor-like receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=89
Introduction to 1H. Liver X receptor-like receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=89
Receptors
Farnesoid X receptor
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=603
Farnesoid X receptor-β
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=604
Liver X receptor-α
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=602
Liver X receptor-β
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=601
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