IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F82/2019.4

Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



William A. Catterall1, Alan L. Goldin2 and Stephen G. Waxman3
  1. University of Washington, USA
  2. University of California, USA
  3. Yale University, USA


Abstract

Sodium channels are voltage-gated sodium-selective ion channels present in the membrane of most excitable cells. Sodium channels comprise of one pore-forming α subunit, which may be associated with either one or two β subunits [176]. α-Subunits consist of four homologous domains (I–IV), each containing six transmembrane segments (S1–S6) and a pore-forming loop. The positively charged fourth transmembrane segment (S4) acts as a voltage sensor and is involved in channel gating. The crystal structure of the bacterial NavAb channel has revealed a number of novel structural features compared to earlier potassium channel structures including a short selectivity filter with ion selectivity determined by interactions with glutamate side chains [268]. Interestingly, the pore region is penetrated by fatty acyl chains that extend into the central cavity which may allow the entry of small, hydrophobic pore-blocking drugs [268]. Auxiliary β1, β2, β3 and β4 subunits consist of a large extracellular N-terminal domain, a single transmembrane segment and a shorter cytoplasmic domain.

The nomenclature for sodium channels was proposed by Goldin et al., (2000) [143] and approved by the NC-IUPHAR Subcommittee on sodium channels (Catterall et al., 2005, [51]).

Contents

This is a citation summary for Voltage-gated sodium channels in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Voltage-gated sodium channels
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=82
Introduction to Voltage-gated sodium channels
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=82
    Channels and Subunits
            Nav1.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=578
            Nav1.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=579
            Nav1.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580
            Nav1.4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=581
            Nav1.5
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=582
            Nav1.6
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=583
            Nav1.7
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=584
            Nav1.8
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=585
            Nav1.9
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=586

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