IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F81/2019.4

Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Bernard Attali1, K. George Chandy2, M. Hunter Giese3, Stephan Grissmer4, George A. Gutman2, Lily Y. Jan5, Michel Lazdunski6, David Mckinnon7, Jeanne Nerbonne8, Luis A. Pardo9, Gail A. Robertson10, Bernardo Rudy11, Michael C. Sanguinetti12, Walter Stühmer9, James S. Trimmer13 and Xiaoliang Wang14
  1. Tel Aviv University, Israel
  2. University of California Irvine, USA
  3. Columbia University, USA
  4. Ulm University, Germany
  5. University of California San Francisco, USA
  6. CNRS Valbonne, France
  7. State University of New York at Stony Brook, USA
  8. Washington University, USA
  9. Max Planck Institute for Experimental Medicine, Germany
  10. University of Wisconsin-Madison, USA
  11. New York University, USA
  12. University of Utah, USA
  13. University of California Davis, USA
  14. Peking Union Medical College, China


Abstract

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

Contents

This is a citation summary for Voltage-gated potassium channels in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Voltage-gated potassium channels
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=81
Introduction to Voltage-gated potassium channels
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=81
    Channels and Subunits
            Kv1.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=538
            Kv1.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=539
            Kv1.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=540
            Kv1.4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=541
            Kv1.5
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542
            Kv1.6
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=543
            Kv1.7
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=544
            Kv1.8
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=545
            Kv2.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=546
            Kv2.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=547
            Kv3.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=548
            Kv3.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=549
            Kv3.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=550
            Kv3.4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=551
            Kv4.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=552
            Kv4.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=553
            Kv4.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=554
            Kv5.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=555
            Kv6.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=556
            Kv6.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=557
            Kv6.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=558
            Kv6.4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=559
            Kv7.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=560
            Kv7.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=561
            Kv7.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=562
            Kv7.4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=563
            Kv7.5
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=564
            Kv8.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=565
            Kv8.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=566
            Kv9.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=567
            Kv9.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=568
            Kv9.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=569
            Kv10.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=570
            Kv10.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=571
            Kv11.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=572
            Kv11.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=573
            Kv11.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=574
            Kv12.1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=575
            Kv12.2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=576
            Kv12.3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=577

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