IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F64/2019.4

Trace amine receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Tom I. Bonner1, Anthony P. Davenport2, Stephen M. Foord3, Janet J. Maguire2 and William A.E. Parker2
  1. National Institute of Mental Health, USA
  2. University of Cambridge, UK
  3. GlaxoSmithKline, UK


Abstract

Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Trace amine receptor [53]) has affinity for the endogenous trace amines tyramine, β-phenylethylamine and octopamine in addition to the classical amine dopamine [9]. Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain [90] with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed [28]. In addition to trace amines, receptors can be activated by amphetamine-like psychostimulants, and endogenous thyronamines.

Contents

This is a citation summary for Trace amine receptor in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Trace amine receptor
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=64
Introduction to Trace amine receptor
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=64
    Receptors
            TA1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=364

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