IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F56/2019.4

Prokineticin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Rebecca Hills1, Philippe Rondard2, Oualid Sbai2 and Qun-Yong Zhou3
  1. University of Edinburgh, UK
  2. Université de Montpellier, France
  3. University of California Irvine, USA


Abstract

Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [23]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [65]) is a potent, non-selective agonist at prokineticin receptors [41], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [44]), is equipotent at recombinant PKR1 and PKR2 [48], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.

Contents

This is a citation summary for Prokineticin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Prokineticin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=56
Introduction to Prokineticin receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=56
    Receptors
            PKR1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=335
            PKR2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=336

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