IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F54/2019.4

QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Didier Bagnol1, Tom I. Bonner2, Myrna Carlebur3, Anthony P. Davenport3, Stephen M. Foord4, Shoji Fukusumi5, Riccarda Granata6, Dan Larhammar7, Jérôme Leprince8, Janet J. Maguire3, Stefany D. Primeaux9 and Hubert Vaudry8
  1. Arena Pharmaceuticals, USA
  2. National Institute of Mental Health, USA
  3. University of Cambridge, UK
  4. GlaxoSmithKline, UK
  5. University of Tsukuba, Japan
  6. University of Torino Medical School, Italy
  7. Uppsala University, Sweden
  8. Normandy University, France
  9. Louisiana State University, USA


Abstract

The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [16]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al. from a hypothalamus cDNA library [15]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y2 (37%) and galanin Gal1 (35%) receptors.

Contents

This is a citation summary for QRFP receptor in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

QRFP receptor
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=54
Introduction to QRFP receptor
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=54
    Receptors
            QRFP receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=333

References

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  2. Bruzzone F, Lectez B, Alexandre D, Jégou S, Mounien L, Tollemer H, Chatenet D, Leprince J, Vallarino M and Vaudry H et al.. (2007) Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J. Comp. Neurol. 503: 573-91 [PMID:17534937]
  3. Chartrel N, Bruzzone F, Dujardin C, Leprince J, Tollemer H, Anouar Y, Vallarino M, Costentin J and Vaudry H. (2005) Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. Ann. N. Y. Acad. Sci. 1040: 80-3 [PMID:15891009]
  4. Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Régo JC, Vandesande F, Llorens-Cortes C and Costentin J et al.. (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc. Natl. Acad. Sci. U.S.A. 100: 15247-52 [PMID:14657341]
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