IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F15/2019.4

Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Margery Beinfeld1, Quan Chen2, Fan Gao2, Roger A. Liddle3, Laurence J. Miller2 and Jens Rehfeld4
  1. Tufts University, USA
  2. Mayo Clinic, USA
  3. Duke University, USA
  4. University of Copenhagen, Denmark


Abstract

Cholecystokinin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on CCK receptors [89]) are activated by the endogenous peptides cholecystokinin-8 (CCK-8), CCK-33, CCK-58 and gastrin (gastrin-17). There are only two distinct subtypes of CCK receptors, CCK1 and CCK2 receptors [63, 123], with some alternatively spliced forms most often identified in neoplastic cells. The CCK receptor subtypes are distinguished by their peptide selectivity, with the CCK1 receptor requiring the carboxyl-terminal heptapeptide-amide that includes a sulfated tyrosine for high affinity and potency, while the CCK2 receptor requires only the carboxyl-terminal tetrapeptide shared by each CCK and gastrin peptides. These receptors have characteristic and distinct distributions, with both present in both the central nervous system and peripheral tissues.

Contents

This is a citation summary for Cholecystokinin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Cholecystokinin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=15
Introduction to Cholecystokinin receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=15
    Receptors
            CCK1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=76
            CCK2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=77

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