IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F9/2019.4

Bombesin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Jim Battey1, Richard V. Benya2, Robert T. Jensen1 and Terry W. Moody1
  1. National Institutes of Health, USA
  2. University of Illinois at Chicago, USA


Abstract

Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [109]). BB1 and BB2 are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP-(18-27). bombesin is a tetradecapeptide, originally derived from amphibians. The three Bn receptor subtypes couple primarily to the Gq/11 and G12/13 family of G proteins [109]. Each of these receptors is widely distributed in the CNS and peripheral tissues [73, 109, 236, 265, 226, 348]. Activation of BB1 and BB2 receptors causes a wide range of physiological/pathophysiogical actions, including the stimulation of normal and neoplastic tissue growth, smooth-muscle contraction, feeding behavior, secretion and many central nervous system effects including regulation of circadian rhythm and mediation of pruritus [112, 113, 109, 115, 116, 155, 189, 236]. A physiological role for the BB3 receptor has yet to be fully defined although recently studies suggest an important role in glucose and insulin regulation, metabolic homeostasis, feeding, regulation of body temperature, obesity, diabetes mellitus and growth of normal/neoplastic tissues [73, 157, 203, 332].

Contents

This is a citation summary for Bombesin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Bombesin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=9
Introduction to Bombesin receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=9
    Receptors
            BB1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=38
            BB2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=39
            BB3 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=40

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