IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F1/2019.4

5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Rodrigo Andrade1, Nicholas M. Barnes2, Gordon Baxter3, Joel Bockaert1, Theresa Branchek4, Amy Butler2, Marlene L. Cohen5, Aline Dumuis6, Richard M. Eglen7, Manfred Göthert8, Mark Hamblin9, Michel Hamon10, Paul R. Hartig11, René Hen12, Julie Hensler13, Katharine Herrick-Davis14, Rebecca Hills15, Daniel Hoyer16, Patrick P. A. Humphrey17, Klaus Peter Latté18, Luc Maroteaux19, Graeme R. Martin20, Derek N. Middlemiss21, Ewan Mylecharane22, John Neumaier23, Stephen J. Peroutka24, John A. Peters25, Bryan Roth26, Pramod R. Saxena27, Trevor Sharp28, Andrew Sleight29, Carlos M. Villalon30 and Frank Yocca31
  1. Wayne State University, USA
  2. University of Birmingham, UK
  3. Pharmagene Laboratories, UK
  4. Synaptic Pharmaceutical Corporation, USA
  5. Lilly Research Laboratories, USA
  6. Université de Montpellier, France
  7. PerkinElmer, UK
  8. Universität Bonn, Germany
  9. Puget Sound Geriatric Research Education and Clinical Center, USA
  10. Sorbonne Université, France
  11. DuPont-Merck Pharmaceutical Company, USA
  12. Columbia University, USA
  13. University of Texas, USA
  14. Albany Medical College, USA
  15. University of Edinburgh, UK
  16. University of Melbourne, Australia
  17. University of Cambridge, UK
  18. Axxonis Pharma AG, Germany
  19. Sorbonne University, France
  20. Discovery-Insight, USA
  21. GlaxoSmithKline, UK
  22. University of Sydney, Australia
  23. University of Washington, USA
  24. PPD Pharmaceuticals, USA
  25. University of Dundee, UK
  26. University of North Carolina, USA
  27. Erasmus Universiteit Rotterdam, The Netherlands
  28. University of Oxford, UK
  29. Hoffman-La Roche, Switzerland
  30. Cinvestav, Mexico
  31. Bristol-Myers Squibb, USA


Abstract

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 482]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [463, 382]).

Contents

This is a citation summary for 5-Hydroxytryptamine receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

5-Hydroxytryptamine receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1
Introduction to 5-Hydroxytryptamine receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=1
    Receptors
            5-HT1A receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1
            5-HT1B receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2
            5-HT1D receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3
            5-ht1e receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=4
            5-HT1F receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=5
            5-HT2A receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=6
            5-HT2B receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=7
            5-HT2C receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=8
            5-HT4 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9
            5-HT5A receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=10
            5-ht5b receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=648
            5-HT6 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11
            5-HT7 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=12

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