IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F792/2025.3

Type VI RTKs: PTK7/CCK4 in GtoPdb v.2025.3



Chloe J. Peach1
  1. University of Nottingham, UK


Abstract

The PTK7 receptor is associated with polarization of epithelial cells and the development of neural structures. Sequence analysis suggests that the gene product is catalytically inactive as a protein kinase, hence acting as a pseudokinase. There is, however, evidence for a role in Wnt signalling [2], as well as an ability to form heteromers with other RTKs, such as VEGFR2 and ROR2.

Contents

This is a citation summary for Type VI RTKs: PTK7/CCK4 in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [1].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Type VI RTKs: PTK7/CCK4
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=792
    Receptors
            CCK4(protein tyrosine kinase 7 (inactive))
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1848

References

  1. Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020) Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
  2. Puppo F, Thomé V, Lhoumeau AC, Cibois M, Gangar A, Lembo F, Belotti E, Marchetto S, Lécine P and Prébet T et al.. (2011) Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling. EMBO Rep 12: 43-9 [PMID:21132015]