TY - JOUR AU - Stephen P.H. Alexander AU - Patrick Doherty AU - David Fairlie AU - Christopher J. Fowler AU - Christopher M. Overall AU - Neil Rawlings AU - Christopher Southan AU - Anthony J. Turner PY - 2019/09/16 Y2 - 2024/03/29 TI - Hydrolases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database JF - IUPHAR/BPS Guide to Pharmacology CITE JA - GtoPdb CITE VL - 2019 IS - 4 SE - Summaries DO - 10.2218/gtopdb/F799/2019.4 UR - http://journals.ed.ac.uk/gtopdb-cite/article/view/3285 AB - Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins. ER -