TY - JOUR AU - Dominique Bataille AU - Susan L. Chan AU - Philippe Delagrange AU - Daniel J. Drucker AU - Burkhard Göke AU - Rebecca Hills AU - Kelly E. Mayo AU - Laurence J. Miller AU - Roberto Salvatori AU - Bernard Thorens PY - 2019/09/16 Y2 - 2024/03/29 TI - Glucagon receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database JF - IUPHAR/BPS Guide to Pharmacology CITE JA - GtoPdb CITE VL - 2019 IS - 4 SE - Summaries DO - 10.2218/gtopdb/F29/2019.4 UR - http://journals.ed.ac.uk/gtopdb-cite/article/view/3183 AB - The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [159]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [116]. For a recent review on review the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the signaling events associated with it, see de Graaf et al., 2016 [87]. ER -