TY - JOUR AU - Bertil B. Fredholm AU - Bruno G. Frenguelli AU - Rebecca Hills AU - Adriaan P. IJzerman AU - Kenneth A. Jacobson AU - Karl-Norbert Klotz AU - Joel Linden AU - Christa E. Müller AU - Ulrich Schwabe AU - Gary L. Stiles PY - 2019/09/16 Y2 - 2024/03/28 TI - Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database JF - IUPHAR/BPS Guide to Pharmacology CITE JA - GtoPdb CITE VL - 2019 IS - 4 SE - Summaries DO - 10.2218/gtopdb/F3/2019.4 UR - http://journals.ed.ac.uk/gtopdb-cite/article/view/3157 AB - Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [103]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [146, 305, 213, 55], agonist-bound [362, 196, 198] and G protein-bound A2A adenosine receptors [43] have been described. The structures of an antagonist-bound A1 receptor [123] and an adenosine-bound A1 receptor-Gi complex [80] have been resolved by cryo-electronmicroscopy. Another structure of an antagonist-bound A1 receptor obtained with X-ray crystallography has also been reported [51]. ER -