SLC66 Lysosomal amino acid transporters in GtoPdb v.2023.1

Gergely Gyimesi; Matthias A. Hediger

doi:10.2218/gtopdb/F1048/2023.1

SLC66 Lysosomal amino acid transporters in GtoPdb v.2023.1

Gergely Gyimesi Universität Bern https://orcid.org/0000-0002-2054-4633
Matthias A. Hediger Universität Bern https://orcid.org/0000-0003-1946-027X

Abstract

This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin), primarily exporting amino acids from the lysosome to the cytoplasm. The functions of the 3 remaining members of the family are undetermined.

DOI: https://doi.org/10.2218/gtopdb/F1048/2023.1

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Published

26-Apr-2023

How to Cite

Gyimesi, G. and Hediger, M. A. (2023) “SLC66 Lysosomal amino acid transporters in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F1048/2023.1.

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Issue

Vol 2023 No 1 (2023)

Section

Summaries

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