Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2023.1

  • Stephanie Annett RCSI, University of Medicine and Health Sciences
  • Tracy Robson RCSI, University of Medicine and Health Sciences

Abstract


Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [62], and family members have been targetted for immunosuppressant effects.

DOI: https://doi.org/10.2218/gtopdb/F845/2023.1
Published
26-Apr-2023
How to Cite
Annett, S. and Robson, T. (2023) “Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F845/2023.1.
Issue
Vol 2023 No 1 (2023)
Section
Summaries
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