ABCG subfamily in GtoPdb v.2023.1

  • Ian Kerr University of Nottingham

Abstract


This family of 'half-transporters' act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. The ABCG5/ABCG heterodimer sterol transporter structure has been determined [6], suggesting an extensive intracellular nucleotide binding domain linked to the transmembrane domains by a fold in the primary sequence. The functional ABCG2 transporter appears to be a homodimer with structural similarities to the ABCG5/ABCG8 heterodimer [10, 1].

Published
26-Apr-2023
How to Cite
Kerr, I. (2023) “ABCG subfamily in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F155/2023.1.
Section
Summaries