1H. Liver X receptor-like receptors in GtoPdb v.2023.1

  • Donald P. McDonnell Duke University
  • Rachid Safi Duke University

Abstract


Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [76, 3]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [80].

Published
26-Apr-2023
How to Cite
McDonnell, D. P. and Safi, R. (2023) “1H. Liver X receptor-like receptors in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F89/2023.1.
Section
Summaries