Trace amine receptor in GtoPdb v.2023.1

Tom I. Bonner; Anthony P. Davenport; Stephen M. Foord; Janet J. Maguire; William A.E. Parker

doi:10.2218/gtopdb/F64/2023.1

Tom I. Bonner National Institute of Mental Health
Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
Stephen M. Foord GlaxoSmithKline
Janet J. Maguire University of Cambridge https://orcid.org/0000-0002-9254-7040
William A.E. Parker University of Cambridge

Abstract

Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families. The TA₁ receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Trace amine receptor [58]) has affinity for the endogenous trace amines tyramine, β-phenylethylamine and octopamine in addition to the classical amine dopamine [9]. Emerging evidence suggests that TA₁ is a modulator of monoaminergic activity in the brain [94] with TA₁ and dopamine D₂ receptors shown to form constitutive heterodimers when co-expressed [30]. In addition to trace amines, receptors can be activated by amphetamine-like psychostimulants, and endogenous thyronamines.

DOI: https://doi.org/10.2218/gtopdb/F64/2023.1