Thyrotropin-releasing hormone receptors in GtoPdb v.2023.1

Anthony P. Davenport; Marvin Gershengorn; Rebecca Hills

doi:10.2218/gtopdb/F63/2023.1

Thyrotropin-releasing hormone receptors in GtoPdb v.2023.1

Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
Marvin Gershengorn National Institutes of Health
Rebecca Hills University of Edinburgh

Abstract

Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [14]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH₁ and TRH₂ receptors [29]. [³H]TRH (human, mouse, rat) is able to label both TRH₁ and TRH₂ receptors with K_d values of 13 and 9 nM respectively. Synthesis and biology of ring-modified L-Histidine containing TRH analogues has been reported [23].

DOI: https://doi.org/10.2218/gtopdb/F63/2023.1

Published

26-Apr-2023

How to Cite

Davenport, A. P., Gershengorn, M. and Hills, R. (2023) “Thyrotropin-releasing hormone receptors in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F63/2023.1.

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Issue

Vol 2023 No 1 (2023)

Section

Summaries

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