Prokineticin receptors in GtoPdb v.2023.1

Rebecca Hills; Adam J Pawson; Philippe Rondard; Oualid Sbai; Qun-Yong Zhou

doi:10.2218/gtopdb/F56/2023.1

Rebecca Hills University of Edinburgh
Adam J Pawson The University of Edinburgh https://orcid.org/0000-0003-2280-845X
Philippe Rondard Université de Montpellier https://orcid.org/0000-0003-1134-2738
Oualid Sbai Université de Montpellier
Qun-Yong Zhou University of California Irvine

Abstract

Prokineticin receptors, PKR₁ and PKR₂ (provisional nomenclature as recommended by NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [71]) is a potent, non-selective agonist at prokineticin receptors [46], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [49]), is equipotent at recombinant PKR₁ and PKR₂ [53], and has high potency in macrophage chemotaxis assays, which are lost in PKR₁-null mice.

DOI: https://doi.org/10.2218/gtopdb/F56/2023.1