Platelet-activating factor receptor in GtoPdb v.2023.1

  • Rebecca Hills University of Edinburgh
  • Satoshi Ishii Akita University
  • Sonia Jancar University of São Paulo
  • Thomas McIntyre Cleveland Clinic Lerner Research Institute
  • Ewa Ninio CNRS Paris
  • Chris O'Neill University of Sydney
  • Francisco Jose Oliveira Rios University of São Paulo
  • Jeffery B. Travers Indiana University
  • Mark Whittaker Evotec

Abstract


Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor (provisional nomenclature recommended by NC-IUPHAR [38]) is activated by PAF and other suggested endogenous ligands are oxidized phosphatidylcholine [74] and lysophosphatidylcholine [98]. It may also be activated by bacterial lipopolysaccharide [91].

DOI: https://doi.org/10.2218/gtopdb/F55/2023.1
Published
26-Apr-2023
How to Cite
Hills, R., Ishii, S., Jancar, S., McIntyre, T., Ninio, E., O’Neill, C., Oliveira Rios, F. J., Travers, J. B. and Whittaker, M. (2023) “Platelet-activating factor receptor in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F55/2023.1.
Issue
Vol 2023 No 1 (2023)
Section
Summaries
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