Hydroxycarboxylic acid receptors in GtoPdb v.2023.1

Steven L. Colletti; Adriaan P. IJzerman; Timothy W. Lovenberg; Stefan Offermanns; Graeme Semple; M. Gerard Waters; Alan Wise

doi:10.2218/gtopdb/F48/2023.1

Hydroxycarboxylic acid receptors in GtoPdb v.2023.1

Steven L. Colletti Merck Research Laboratories
Adriaan P. IJzerman Leiden University https://orcid.org/0000-0002-1182-2259
Timothy W. Lovenberg Janssen Research & Development
Stefan Offermanns Goethe-University Frankfurt https://orcid.org/0000-0001-8676-6805
Graeme Semple Beacon Discovery Inc https://orcid.org/0000-0002-9666-1588
M. Gerard Waters Merck Research Laboratories
Alan Wise GlaxoSmithKline

Abstract

The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic acid receptors [36, 12]) respond to organic acids, including the endogenous hydroxy carboxylic acids 3-hydroxy butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [53, 60, 65]. These receptors were provisionally described as nicotinic acid receptors, although nicotinic acid shows submicromolar potency at HCA₂receptors only and is unlikely to be the natural ligand [60, 65].

DOI: https://doi.org/10.2218/gtopdb/F48/2023.1

Published

26-Apr-2023

How to Cite

Colletti, S. L., IJzerman, A. P., Lovenberg, T. W., Offermanns, S., Semple, G., Waters, M. G. and Wise, A. (2023) “Hydroxycarboxylic acid receptors in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F48/2023.1.

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Issue

Vol 2023 No 1 (2023)

Section

Summaries

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