Glycoprotein hormone receptors in GtoPdb v.2023.1

  • Sabine Costagliola Université Libre de Bruxelles
  • James A. Dias New York State Department of Health
  • Marvin Gershengorn National Institutes of Health
  • Adam J Pawson The University of Edinburgh https://orcid.org/0000-0003-2280-845X
  • Deborah L. Segaloff University of Iowa
  • Axel P.N. Themmen Erasmus University Medical Cente
  • Gilbert Vassart Université Libre de Bruxelles

Abstract


Glycoprotein hormone receptors (provisional nomenclature [47]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [122, 31].

Published
26-Apr-2023
How to Cite
Costagliola, S., Dias, J. A., Gershengorn, M., Pawson, A. J., Segaloff, D. L., Themmen, A. P. and Vassart, G. (2023) “Glycoprotein hormone receptors in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F30/2023.1.
Section
Summaries