Complement peptide receptors in GtoPdb v.2023.1

Antonia Cianciulli; Liam Coulthard; Owen Hawksworth; John D. Lee; Xaria X. Li; Vincenzo Mitolo; Peter Monk; Maria A. Panaro; Trent M. Woodruff

doi:10.2218/gtopdb/F5/2023.1

Complement peptide receptors in GtoPdb v.2023.1

Antonia Cianciulli University of Bari
Liam Coulthard University of Queensland
Owen Hawksworth University of Queensland
John D. Lee University of Queensland https://orcid.org/0000-0002-9976-7396
Xaria X. Li The University of Queensland https://orcid.org/0000-0001-5924-2977
Vincenzo Mitolo University of Bari
Peter Monk Sheffield University Medical School https://orcid.org/0000-0003-4637-3059
Maria A. Panaro University of Bari
Trent M. Woodruff University of Queensland https://orcid.org/0000-0003-1382-911X

Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3a receptor, C5a receptor 1 and C5a receptor 2), causing cell recruitment and triggering cellular degranulation that contributes to local inflammation.

DOI: https://doi.org/10.2218/gtopdb/F5/2023.1

Published

26-Apr-2023

How to Cite

Cianciulli, A., Coulthard, L., Hawksworth, O., Lee, J. D., Li, X. X., Mitolo, V., Monk, P., Panaro, M. A. and Woodruff, T. M. (2023) “Complement peptide receptors in GtoPdb v.2023.1”, IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi: 10.2218/gtopdb/F5/2023.1.

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Issue

Vol 2023 No 1 (2023)

Section

Summaries

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