Class A Orphans in GtoPdb v.2022.3


Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [121]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).
How to Cite
Alexander, S. P., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Dhanachandra Singh, K., Eguchi, S., Harmar, A., Holliday, N., Jensen, R. T., Karnik, S., Kostenis, E., Liew, W. C., Monaghan, A. E., Mpamhanga, C., Neubig, R., Pawson, A. J., Pin, J.-P., Sharman, J. L., Spedding, M., Spindel, E., Stoddart, L., Storjohann, L., Thomas, W. G., Tirupula, K. and Vanderheyden, P. (2022) “Class A Orphans in GtoPdb v.2022.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2022(3). doi: 10.2218/gtopdb/F16/2022.3.