Chemerin receptors in GtoPdb v.2021.3

Abstract


Nomenclature for the chemerin receptors is presented as recommended by NC-IUPHAR [15, 43]). The chemoattractant protein and adipokine, chemerin, has been shown to be the endogenous ligand for both chemerin family receptors. Chemerin1 was the founding family member, and when GPR1 was de-orphanised it was re-named Chermerin2 [43]. Chemerin1 is also activated by the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1), which is formed via the sequential metabolism of EPA by aspirin-modified cyclooxygenase and lipoxygenase [2, 3]. In addition, two GPCRs for resolvin D1 (RvD1) have been identified: FPR2/ALX, the lipoxin A4 receptor, and GPR32, an orphan receptor [45].

Published
02-Sep-2021
How to Cite
Davenport, A. P. and Monaghan, A. E. (2021) “Chemerin receptors in GtoPdb v.2021.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi: 10.2218/gtopdb/F338/2021.3.
Section
Summaries