3C. 3-Ketosteroid receptors in GtoPdb v.2021.3

  • Derek Cain National Institutes of Health
  • John Cidlowski National Institutes of Health https://orcid.org/0000-0003-1420-0516
  • Dean P. Edwards Baylor College of Medicine
  • Peter Fuller Hudson Instiitute of Medical Research
  • Sandra L. Grimm Baylor College of Medicine
  • Sean Hartig Baylor College of Medicine
  • Carol A. Lange University of Minnesota
  • Robert H. Oakley National Institutes of Health
  • Jennifer K. Richer University of Colorado
  • Carol A. Sartorius University of Colorado
  • Marc Tetel Wellesley College
  • Nancy Weigel Baylor College of Medicine
  • Morag J. Young Baker Heart and Diabetes Institute

Abstract


Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [74, 215, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol.

DOI: https://doi.org/10.2218/gtopdb/F98/2021.3
Published
02-Sep-2021
How to Cite
Cain, D., Cidlowski, J., Edwards, D. P., Fuller, P., Grimm, S. L., Hartig, S., Lange, C. A., Oakley, R. H., Richer, J. K., Sartorius, C. A., Tetel, M., Weigel, N. and Young, M. J. (2021) “3C. 3-Ketosteroid receptors in GtoPdb v.2021.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi: 10.2218/gtopdb/F98/2021.3.
Issue
Vol 2021 No 3 (2021)
Section
Summaries
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