Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2021.3

  • Bernard Attali Tel Aviv University https://orcid.org/0000-0003-1066-7047
  • K. George Chandy University of California Irvine
  • M. Hunter Giese Columbia University
  • Stephan Grissmer Ulm University
  • George A. Gutman University of California Irvine
  • Lily Y. Jan University of California San Francisco
  • Michel Lazdunski CNRS Valbonne
  • David Mckinnon State University of New York at Stony Brook
  • Jeanne Nerbonne Washington University
  • Luis A. Pardo Max Planck Institute for Experimental Medicine
  • Gail A. Robertson University of Wisconsin-Madison
  • Bernardo Rudy New York University
  • Michael C. Sanguinetti University of Utah
  • Walter Stühmer Max Planck Institute for Experimental Medicine
  • James S. Trimmer University of California Davis
  • Xiaoliang Wang Peking Union Medical College

Abstract


The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

DOI: https://doi.org/10.2218/gtopdb/F81/2021.3
Published
02-Sep-2021
How to Cite
Attali, B., Chandy, K. G., Giese, M. H., Grissmer, S., Gutman, G. A., Jan, L. Y., Lazdunski, M., Mckinnon, D., Nerbonne, J., Pardo, L. A., Robertson, G. A., Rudy, B., Sanguinetti, M. C., Stühmer, W., Trimmer, J. S. and Wang, X. (2021) “Voltage-gated potassium channels (K<sub>v</sub&gt;) in GtoPdb v.2021.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi: 10.2218/gtopdb/F81/2021.3.
Issue
Vol 2021 No 3 (2021)
Section
Summaries
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