Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3

Richard Aldrich; K. George Chandy; Stephan Grissmer; George A. Gutman; Leonard K. Kaczmarek; Aguan D. Wei; Heike Wulff

doi:10.2218/gtopdb/F69/2021.3

Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3

Richard Aldrich Stanford University https://orcid.org/0000-0001-7254-5876
K. George Chandy University of California Irvine
Stephan Grissmer Ulm University
George A. Gutman University of California Irvine
Leonard K. Kaczmarek Yale University https://orcid.org/0000-0001-5128-6326
Aguan D. Wei Washington University
Heike Wulff University of California Davis

Abstract

Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated K_Vsubfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca²⁺-activated Slo subfamily (actually with 6 or 7TM) and the Ca²⁺- and Na⁺-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [125]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. K_V1.1 with K_V1.2; KCNQ2 with KCNQ3).

DOI: https://doi.org/10.2218/gtopdb/F69/2021.3

Published

02-Sep-2021

How to Cite

Aldrich, R., Chandy, K. G., Grissmer, S., Gutman, G. A., Kaczmarek, L. K., Wei, A. D. and Wulff, H. (2021) “Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi: 10.2218/gtopdb/F69/2021.3.

Download Citation

Issue

Vol 2021 No 3 (2021)

Section

Summaries

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Calcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>) in GtoPdb v.2021.3

Abstract