Parathyroid hormone receptors in GtoPdb v.2021.3

Alessandro Bisello; Michael Chorev; Peter A. Friedman; Tom Gardella; Rebecca Hills; Harald Jueppner; T. John Martin; Robert A. Nissenson; John Thomas Potts, Jr.; Caroline Silve; Ted B. Usdin; Jean-Pierre Vilardaga

doi:10.2218/gtopdb/F53/2021.3

Alessandro Bisello University of Pittsburgh
Michael Chorev Harvard Medical School
Peter A. Friedman University of Pittsburgh
Tom Gardella Massachusetts General Hospital
Rebecca Hills University of Edinburgh
Harald Jueppner Massachusetts General Hospital
T. John Martin University of Melbourne
Robert A. Nissenson University of California San Francisco
John Thomas Potts, Jr. Massachusetts General Hospital
Caroline Silve INSERM
Ted B. Usdin National Institute of Mental Health
Jean-Pierre Vilardaga University of Pittsburgh

Abstract

The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [49]) are class B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [¹²⁵I]PTH may be used to label both PTH1 and PTH2 receptors. The structure of a long-active PTH analogue (LA-PTH, an hybrid of PTH-(1-13) and PTHrP-(14-36)) bound to the PTH1 receptor-G_s complex has been resolved by cryo-electron microscopy [147]. Another structure of a PTH-(1-34) analog bound to a thermostabilized inactive PTH1 receptor has been obtained with X-ray crytallography [34].

DOI: https://doi.org/10.2218/gtopdb/F53/2021.3