Glucagon receptor family in GtoPdb v.2021.3

  • Dominique Bataille INSERM
  • Susan L. Chan University of Nottingham
  • Philippe Delagrange Servier
  • Daniel J. Drucker University of Toronto
  • Burkhard Göke University of Hamburg
  • Rebecca Hills University of Edinburgh
  • Kelly E. Mayo Northwestern University
  • Laurence J. Miller Mayo Clinic https://orcid.org/0000-0002-4554-3872
  • Roberto Salvatori Johns Hopkins Hospital
  • Bernard Thorens University of Lausanne

Abstract


The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [162]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [119]. For a recent review on the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the associated signaling events see de Graaf et al., 2016 [89].

Published
02-Sep-2021
How to Cite
Bataille, D., Chan, S. L., Delagrange, P., Drucker, D. J., Göke, B., Hills, R., Mayo, K. E., Miller, L. J., Salvatori, R. and Thorens, B. (2021) “Glucagon receptor family in GtoPdb v.2021.3”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi: 10.2218/gtopdb/F29/2021.3.
Section
Summaries