Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2

  • Stephanie Annett RCSI, University of Medicine and Health Sciences
  • Tracy Robson RCSI, University of Medicine and Health Sciences

Abstract


Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [59], and family members have been targetted for immunosuppressant effects.

Published
25-Jun-2021
How to Cite
Annett, S. and Robson, T. (2021) “Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2”, IUPHAR/BPS Guide to Pharmacology CITE, 2021(2). doi: 10.2218/gtopdb/F845/2021.2.
Section
Summaries