Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Stephen P.H. Alexander; Jim Battey; Helen E. Benson; Richard V. Benya; Tom I. Bonner; Anthony P. Davenport; Khuraijam Dhanachandra Singh; Satoru Eguchi; Anthony Harmar; Nick Holliday; Robert T. Jensen; Sadashiva Karnik; Evi Kostenis; Wen Chiy Liew; Amy E. Monaghan; Chido Mpamhanga; Richard Neubig; Adam J. Pawson; Jean-Philippe Pin; Joanna L. Sharman; Michael Spedding; Eliot Spindel; Leigh Stoddart; Laura Storjohann; Walter G. Thomas; Kalyan Tirupula; Patrick Vanderheyden

doi:10.2218/gtopdb/F16/2020.5

Stephen P.H. Alexander University of Nottingham https://orcid.org/0000-0003-4417-497X
Jim Battey National Institutes of Health
Helen E. Benson University of Edinburgh
Richard V. Benya University of Illinois at Chicago
Tom I. Bonner National Institute of Mental Health
Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
Khuraijam Dhanachandra Singh Cleveland Clinic Lerner Research Institute https://orcid.org/0000-0003-0506-6896
Satoru Eguchi Temple University
Anthony Harmar University of Edinburgh
Nick Holliday University of Nottingham https://orcid.org/0000-0002-2900-828X
Robert T. Jensen National Institutes of Health
Sadashiva Karnik Cleveland Clinic Lerner Research Institute
Evi Kostenis University of Bonn https://orcid.org/0000-0001-8284-5514
Wen Chiy Liew University of Edinburgh
Amy E. Monaghan University of Edinburgh
Chido Mpamhanga LifeArc
Richard Neubig Michigan State University https://orcid.org/0000-0003-0501-0008
Adam J. Pawson The University of Edinburgh https://orcid.org/0000-0003-2280-845X
Jean-Philippe Pin Université de Montpellier https://orcid.org/0000-0002-1423-345X
Joanna L. Sharman University of Edinburgh https://orcid.org/0000-0002-5275-6446
Michael Spedding Spedding Research Solutions SARL https://orcid.org/0000-0002-1248-8221
Eliot Spindel Oregon Health & Science University
Leigh Stoddart University of Glasgow https://orcid.org/0000-0002-4469-0600
Laura Storjohann University of Utah
Walter G. Thomas University of Queensland
Kalyan Tirupula Cleveland Clinic Lerner Research Institute
Patrick Vanderheyden Vrije Universiteit Brussel

Abstract

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [194], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [150]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

GPR3 GPR4 GPR6 GPR12 GPR15 GPR17 GPR20 GPR22 GPR26 GPR31 GPR34 GPR35 GPR37 GPR39 GPR50 GPR63 GRP65 GPR68 GPR75 GPR84 GPR87 GPR88 GPR132 GPR149 GPR161 GPR183 LGR4 LGR5 LGR6 MAS1 MRGPRD MRGPRX1 MRGPRX2 P2RY10 TAAR2
In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

DOI: https://doi.org/10.2218/gtopdb/F16/2020.5