SLC51 family of steroid-derived molecule transporters C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The SLC51 organic solute transporter family of transporters is a pair of heterodimeric proteins which regulate bile salt movements in the small intestine, bile duct, and liver, as part of the enterohepatic circulation [1-2,4]. OSTα/OSTβ is also expressed in steroidogenic cells of the brain and adrenal gland, where it may contribute to steroid sulphate movement [5]. Bile acid and steroid sulphate transport is suggested to be facilitative and independent of sodium, potassium, chloride ions or protons [2,4]. OSTα/OSTβ heterodimers have been shown to transport [3H]taurocholic acid, [3H]dehydroepiandrosterone sulphate, [3H]estrone-3-sulphate, [3H]pregnenolone sulphate and [3H]dehydroepiandrosterone sulphate[2,4-5]. OSTα/OSTβ-mediated transport is inhibited by clofazimine and fidaxomicin [8,10]. OSTα is suggested to be a seven TM protein, while OSTβ is a single TM 'ancillary' protein, both of which are thought to have intracellular C-termini [7]. Both proteins function in solute transport [3,7]. Inherited mutations in OSTα and OSTβ are associated with liver disease and congenital diarrhea in children [6,9].
Transporters
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OSTα (Organic solute transporter subunit α / SLC51A1) C Show summary » |
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OSTβ (Organic solute transporter subunit β / SLC51B) C Show summary » |
Further reading
How to cite this family page
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.
