Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Richard M. Breyer; Lucie Clapp; Robert A. Coleman; Mark Giembycz; Akos Heinemann; Rebecca Hills; Robert L. Jones; Shuh Narumiya; Xavier Norel; Roy Pettipher; Yukihiko Sugimoto; Mohib Uddin; David F. Woodward; Chengcan Yao

doi:10.2218/gtopdb/F58/2020.4

Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Richard M. Breyer Vanderbilt University
Lucie Clapp University College London https://orcid.org/0000-0001-7802-4481
Robert A. Coleman Pharmagene Laboratories
Mark Giembycz University of Calgary
Akos Heinemann Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation) https://orcid.org/0000-0002-8554-2372
Rebecca Hills University of Edinburgh
Robert L. Jones University of Strathclyde
Shuh Narumiya Kyoto University Faculty of Medicine
Xavier Norel Laboratory for Vascular Translational Science https://orcid.org/0000-0003-0734-3359
Roy Pettipher Atopix Therapeutics Ltd
Yukihiko Sugimoto Kumamoto University
Mohib Uddin AstraZeneca https://orcid.org/0000-0002-2412-2657
David F. Woodward Allergan plc
Chengcan Yao University of Edinburgh https://orcid.org/0000-0003-3754-2842

Abstract

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [661]) are activated by the endogenous ligands prostaglandins PGD₂, PGE₁, PGE₂ , PGF_2α, PGH₂, prostacyclin [PGI₂] and thromboxane A₂. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [423]. Measurement of the potency of PGI₂ and thromboxane A₂ is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

DOI: https://doi.org/10.2218/gtopdb/F58/2020.4

Published

24-Sep-2020

How to Cite

Breyer, R. M., Clapp, L., Coleman, R. A., Giembycz, M., Heinemann, A., Hills, R., Jones, R. L., Narumiya, S., Norel, X., Pettipher, R., Sugimoto, Y., Uddin, M., Woodward, D. F. and Yao, C. (2020) “Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2020(4). doi: 10.2218/gtopdb/F58/2020.4.

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Issue

Vol 2020 No 4 (2020)

Section

Summaries

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