Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database

  • Annie Beuve Rutgers University
  • Peter Brouckaert Vlaams Instituut voor Biotechnologie
  • John C. Burnett, Jr. Mayo Clinic
  • Andreas Friebe Universität Würzburg
  • John Garthwaite University College London
  • Adrian J. Hobbs Queen Mary University of London
  • Doris Koesling Ruhr-Universität Bochum
  • Michaela Kuhn Physiologisches Institut der Universität Würzburg
  • Lincoln R. Potter University of Minnesota
  • Michael Russwurm Ruhr University Bochum
  • Harald H.H.W. Schmidt Maastricht University
  • Johannes-Peter Stasch Bayer AG
  • Scott A. Waldman Thomas Jefferson University


The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.

How to Cite
Beuve, A., Brouckaert, P., Burnett, Jr., J. C., Friebe, A., Garthwaite, J., Hobbs, A. J., Koesling, D., Kuhn, M., Potter, L. R., Russwurm, M., Schmidt, H. H., Stasch, J.-P. and Waldman, S. A. (2020) “Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2020(3). doi: 10.2218/gtopdb/F1022/2020.3.