Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Mohammed Alqinyah University of Georgia
  • Christopher Bodle University of Iowa
  • Josephine Bou Dagher University of Georgia
  • Bandana Chakravarti University of Iowa
  • Shreoshi P. Choudhuri University of Texas Southwestern Medical Center
  • Kirk M. Druey National Institutes of Health
  • Rory A. Fisher University of Iowa
  • Kyle J. Gerber Emory University
  • John R. Hepler Emory University
  • Shelley B. Hooks University of Georgia
  • Havish S. Kantheti University of Texas Southwestern Medical Center
  • Behirda Karaj Michigan State University
  • Jae-Kyung Lee University of Georgia
  • Zili Luo University of Iowa
  • Kirill Martemyanov Scripps Research Institute
  • Luke D. Mascarenhas University of Texas Southwestern Medical Center
  • Hoa Phan Thi Nhu Michigan State University
  • David L. Roman University of Iowa
  • Vincent Shaw Michigan State University
  • Benita Sjögren Purdue University https://orcid.org/0000-0003-1460-1045
  • Katherine E. Squires Emory University
  • Laurie Sutton Scripps Research Institute
  • Thomas M. Wilkie University of Texas Southwestern Medical Center https://orcid.org/0000-0002-9357-637X
  • Keqiang Xie Scripps Research Institute
  • Yalda Zolghadri University of Texas Southwestern Medical Center

Abstract


Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading to a termination of GPCR signalling. Interactions through protein:protein interactions of many RGS proteins have been identified for targets other than heteromeric G proteins. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins. Included here is RGS4 for which a number of pharmacological inhibitors have been described.
DOI: https://doi.org/10.2218/gtopdb/F891/2019.4
Published
16-Sep-2019
How to Cite
Alqinyah, M., Bodle, C., Bou Dagher, J., Chakravarti, B., Choudhuri, S. P., Druey, K. M., Fisher, R. A., Gerber, K. J., Hepler, J. R., Hooks, S. B., Kantheti, H. S., Karaj, B., Lee, J.-K., Luo, Z., Martemyanov, K., Mascarenhas, L. D., Phan Thi Nhu, H., Roman, D. L., Shaw, V., Sjögren, B., Squires, K. E., Sutton, L., Wilkie, T. M., Xie, K. and Zolghadri, Y. (2019) “Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F891/2019.4.
Issue
Vol 2019 No 4 (2019)
Section
Summaries
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