Hydrogen sulphide synthesis (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Timothy R. Billiar University of Pittsburgh
  • Giuseppe Cirino University of Naples-Federico II
  • David Fulton Georgia Regents University
  • Roberto Motterlini University of Paris Est Creteil
  • Andreas Papapetropoulos University of Athens https://orcid.org/0000-0002-4253-5930
  • Csaba Szabo University of Texas


Hydrogen sulfide is a gasotransmitter, with similarities to nitric oxide and carbon monoxide. Although the enzymes indicated below have multiple enzymatic activities, the focus here is the generation of hydrogen sulphide (H2S) and the enzymatic characteristics are described accordingly. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are pyridoxal phosphate (PLP)-dependent enzymes. 3-mercaptopyruvate sulfurtransferase (3-MPST) functions to generate H2S; only CAT is PLP-dependent, while 3-MPST is not. Thus, this third pathway is sometimes referred to as PLP-independent. CBS and CSE are predominantly cytosolic enzymes, while 3-MPST is found both in the cytosol and the mitochondria. For an authoritative review on the pharmacological modulation of H2S levels, see Szabo and Papapetropoulos, 2017 [4].
How to Cite
Billiar, T. R., Cirino, G., Fulton, D., Motterlini, R., Papapetropoulos, A. and Szabo, C. (2019) “Hydrogen sulphide synthesis (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F279/2019.4.