ABCA subfamily (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Mary Vore University of Kentucky

Abstract


To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment [1].
Published
16-Sep-2019
How to Cite
Vore, M. (2019) “ABCA subfamily (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F151/2019.4.
Section
Summaries