Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abstract
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
Published
16-Sep-2019
How to Cite
Attali, B., Chandy, K. G., Giese, M. H., Grissmer, S., Gutman, G. A., Jan, L. Y., Lazdunski, M., Mckinnon, D., Nerbonne, J., Pardo, L. A., Robertson, G. A., Rudy, B., Sanguinetti, M. C., Stühmer, W., Trimmer, J. S. and Wang, X. (2019) “Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F81/2019.4.
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