Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • John P. Adelman Oregon Health & Science University
  • David E. Clapham Harvard Medical School
  • Hiroshi Hibino Osaka University
  • Atsushi Inanobe Osaka University
  • Lily Y. Jan University of California San Francisco
  • Andreas Karschin University of Würzburg
  • Yoshihiro Kubo National Institute for Physiological Sciences
  • Yoshihisa Kurachi Osaka University
  • Michel Lazdunski CNRS Valbonne
  • Takashi Miki Kobe University
  • Colin G. Nichols Washington University
  • Lawrence G. Palmer Weill-Cornell Medical College
  • Wade L. Pearson Washington University
  • Henry Sackin Rosalind Franklin University
  • Susumu Seino Kobe University
  • Paul A. Slesinger Icahn School of Medicine at Mount Sinai
  • Stephen Tucker University of Oxford
  • Carol A. Vandenberg University of California Santa Barbara


The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).
How to Cite
Adelman, J. P., Clapham, D. E., Hibino, H., Inanobe, A., Jan, L. Y., Karschin, A., Kubo, Y., Kurachi, Y., Lazdunski, M., Miki, T., Nichols, C. G., Palmer, L. G., Pearson, W. L., Sackin, H., Seino, S., Slesinger, P. A., Tucker, S. and Vandenberg, C. A. (2019) “Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F74/2019.4.