Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

John P. Adelman; David E. Clapham; Hiroshi Hibino; Atsushi Inanobe; Lily Y. Jan; Andreas Karschin; Yoshihiro Kubo; Yoshihisa Kurachi; Michel Lazdunski; Takashi Miki; Colin G. Nichols; Lawrence G. Palmer; Wade L. Pearson; Henry Sackin; Susumu Seino; Paul A. Slesinger; Stephen Tucker; Carol A. Vandenberg

doi:10.2218/gtopdb/F74/2019.4

Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

John P. Adelman Oregon Health & Science University https://orcid.org/0000-0002-1135-1549
David E. Clapham Harvard Medical School
Hiroshi Hibino Osaka University
Atsushi Inanobe Osaka University
Lily Y. Jan University of California San Francisco
Andreas Karschin University of Würzburg
Yoshihiro Kubo National Institute for Physiological Sciences
Yoshihisa Kurachi Osaka University
Michel Lazdunski CNRS Valbonne
Takashi Miki Kobe University
Colin G. Nichols Washington University
Lawrence G. Palmer Weill-Cornell Medical College
Wade L. Pearson Washington University
Henry Sackin Rosalind Franklin University
Susumu Seino Kobe University
Paul A. Slesinger Icahn School of Medicine at Mount Sinai
Stephen Tucker University of Oxford https://orcid.org/0000-0001-8996-2000
Carol A. Vandenberg University of California Santa Barbara

Abstract

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (K_ir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (K_ir3.x) and the ATP-sensitive K channels (K_ir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. K_ir3.2 with K_ir3.3).

DOI: https://doi.org/10.2218/gtopdb/F74/2019.4

Published

16-Sep-2019

How to Cite

Adelman, J. P., Clapham, D. E., Hibino, H., Inanobe, A., Jan, L. Y., Karschin, A., Kubo, Y., Kurachi, Y., Lazdunski, M., Miki, T., Nichols, C. G., Palmer, L. G., Pearson, W. L., Sackin, H., Seino, S., Slesinger, P. A., Tucker, S. and Vandenberg, C. A. (2019) “Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F74/2019.4.

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Issue

Vol 2019 No 4 (2019)

Section

Summaries

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