Urotensin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
  • Stephen A. Douglas Wyeth Pharmaceuticals
  • Alain Fournier Université du Québec
  • Adel Giaid McGill University
  • Henry Krum Monash University
  • David G. Lambert University of Leicester
  • Jérôme Leprince Normandy University https://orcid.org/0000-0002-7814-9927
  • Margaret R. MacLean University of Glasgow
  • Eliot H. Ohlstein Drexel University
  • Walter G. Thomas University of Queensland
  • Hervé Tostivint Muséum National d'Histoire Naturelle
  • David Vaudry Normandy University
  • Hubert Vaudry Normandy University
  • David J. Webb University of Edinburgh https://orcid.org/0000-0003-0755-1756


The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 89]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endocrine organ of the caudal neurosecretory system of teleost fish [7, 88]. Several structural forms of U-II exist in fish and amphibians. The goby orthologue was used to identify U-II as the cognate ligand for the predicted receptor encoded by the rat gene gpr14 [20, 62, 68, 70]. Human urotensin-II, an 11-amino-acid peptide [20], retains the cyclohexapeptide sequence of goby U-II that is thought to be important in ligand binding [53, 11]. This sequence is also conserved in the deduced amino-acid sequence of rat urotensin-II (14 amino-acids) and mouse urotensin-II (14 amino-acids), although the N-terminal is more divergent from the human sequence [19]. A second endogenous ligand for the UT has been discovered in rat [83]. This is the urotensin II-related peptide, an octapeptide that is derived from a different gene, but shares the C-terminal sequence (CFWKYCV) common to U-II from other species. Identical sequences to rat urotensin II-related peptide are predicted for the mature mouse and human peptides [32]. UT exhibits relatively high sequence identity with somatostatin, opioid and galanin receptors [89].
How to Cite
Davenport, A. P., Douglas, S. A., Fournier, A., Giaid, A., Krum, H., Lambert, D. G., Leprince, J., MacLean, M. R., Ohlstein, E. H., Thomas, W. G., Tostivint, H., Vaudry, D., Vaudry, H. and Webb, D. J. (2019) “Urotensin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F65/2019.4.