Platelet-activating factor receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Rebecca Hills University of Edinburgh
  • Satoshi Ishii Akita University
  • Sonia Jancar University of São Paulo
  • Thomas McIntyre Cleveland Clinic Lerner Research Institute
  • Ewa Ninio CNRS Paris
  • Chris O'Neill University of Sydney
  • Francisco Jose Oliveira Rios University of São Paulo
  • Jeffery B. Travers Indiana University
  • Mark Whittaker Evotec


Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor (provisional nomenclature recommended by NC-IUPHAR [37]) is activated by PAF and other suggested endogenous ligands are oxidized phosphatidylcholine [73] and lysophosphatidylcholine [96]. It may also be activated by bacterial lipopolysaccharide [89].
How to Cite
Hills, R., Ishii, S., Jancar, S., McIntyre, T., Ninio, E., O’Neill, C., Oliveira Rios, F. J., Travers, J. B. and Whittaker, M. (2019) “Platelet-activating factor receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F55/2019.4.