QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Didier Bagnol Arena Pharmaceuticals
  • Tom I. Bonner National Institute of Mental Health
  • Myrna Carlebur University of Cambridge
  • Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
  • Stephen M. Foord GlaxoSmithKline
  • Shoji Fukusumi University of Tsukuba
  • Riccarda Granata University of Torino Medical School
  • Dan Larhammar Uppsala University
  • Jérôme Leprince Normandy University https://orcid.org/0000-0002-7814-9927
  • Janet J. Maguire University of Cambridge https://orcid.org/0000-0002-9254-7040
  • Stefany D. Primeaux Louisiana State University
  • Hubert Vaudry Normandy University


The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [16]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al. from a hypothalamus cDNA library [15]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y2 (37%) and galanin Gal1 (35%) receptors.
How to Cite
Bagnol, D., Bonner, T. I., Carlebur, M., Davenport, A. P., Foord, S. M., Fukusumi, S., Granata, R., Larhammar, D., Leprince, J., Maguire, J. J., Primeaux, S. D. and Vaudry, H. (2019) “QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F54/2019.4.