Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Alessandro Bisello University of Pittsburgh
  • Michael Chorev Harvard Medical School
  • Peter A. Friedman University of Pittsburgh
  • Tom Gardella Massachusetts General Hospital
  • Rebecca Hills University of Edinburgh
  • Harald Jueppner Massachusetts General Hospital
  • T. John Martin University of Melbourne
  • Robert A. Nissenson University of California San Francisco
  • John Thomas Potts, Jr. Massachusetts General Hospital
  • Caroline Silve INSERM
  • Ted B. Usdin National Institute of Mental Health
  • Jean-Pierre Vilardaga University of Pittsburgh


The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors.
How to Cite
Bisello, A., Chorev, M., Friedman, P. A., Gardella, T., Hills, R., Jueppner, H., Martin, T. J., Nissenson, R. A., Potts, Jr., J. T., Silve, C., Usdin, T. B. and Vilardaga, J.-P. (2019) “Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F53/2019.4.