Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors ) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications . Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123].
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