Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abstract
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [102]. Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123].
Published
16-Sep-2019
How to Cite
Coleman, P., de Lecea, L., Gotter, A., Hagan, J., Hills, R., Kilduff, T., Kukkonen, J. P., Porter, R., Renger, J., Siegel, J. M., Sutcliffe, G., Upton, N. and Winrow, C. J. (2019) “Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F51/2019.4.
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