Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Jean Mazella; Philippe Sarret; Jean-Pierre Vincent

doi:10.2218/gtopdb/F47/2019.4

Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Jean Mazella CNRS Valbonne https://orcid.org/0000-0002-5627-0742
Philippe Sarret Université de Sherbrooke
Jean-Pierre Vincent CNRS Valbonne

Abstract

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [38]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS₂ receptor. [³H]neurotensin (human, mouse, rat) and [¹²⁵I]neurotensin (human, mouse, rat) may be used to label NTS₁ and NTS₂ receptors at 0.1-0.3 and 3-5 nM concentrations respectively.

DOI: https://doi.org/10.2218/gtopdb/F47/2019.4

Published

16-Sep-2019

How to Cite

Mazella, J., Sarret, P. and Vincent, J.-P. (2019) “Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F47/2019.4.

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Issue

Vol 2019 No 4 (2019)

Section

Summaries

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