Neuropeptide Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Annette Beck-Sickinger Universität Leipzig
  • William F. Colmers University of Alberta
  • Helen M. Cox Kings College London
  • Henri N. Doods Dr Karl Thomae GmbH
  • Herbert Herzog St. Vincent Hospital
  • Dan Larhammar Uppsala University
  • Martin C. Michel Johannes Gutenberg University
  • Remi Quirion McGill University
  • Thue Schwartz University of Copenhagen
  • Thomas Westfall St. Louis University


Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [156]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified as the Y3 receptor has been identified as the CXCR4 chemokine recepter (originally named LESTR, [137]). The y6 receptor is a functional gene product in mouse, absent in rat, but contains a frame-shift mutation in primates producing a truncated non-functional gene [83]. Many of the agonists exhibit differing degrees of selectivity dependent on the species examined. For example, the potency of PP is greater at the rat Y4 receptor than at the human receptor [61]. In addition, many agonists lack selectivity for individual subtypes, but can exhibit comparable potency against pairs of NPY receptor subtypes, or have not been examined for activity at all subtypes. [125I]-PYY or [125I]-NPY can be used to label Y1, Y2, Y5 and y6 subtypes non-selectively, while [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP may be used to label Y5 receptors preferentially (note that cPP denotes chicken peptide sequence and hPP is the human sequence).
How to Cite
Beck-Sickinger, A., Colmers, W. F., Cox, H. M., Doods, H. N., Herzog, H., Larhammar, D., Michel, M. C., Quirion, R., Schwartz, T. and Westfall, T. (2019) “Neuropeptide Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F46/2019.4.